CURRICULUM VITAE
Kung-Kai Kuo MD, PhD
Current appointment:
Professor in Surgery,
Director, Taiwan Surgical Society of Gastroenterology
Executive Director, Taiwan Society of Surgical Metabolism and Nutrition
Immediate Past President, International College of Surgeons, Taiwan section 2020-21
Clinical appointment
8/2020-7/2021 Chairman, Digestive Diseases Center, KMUH
8/2018-7/2020 Director in General and Digestive Surgery, KMUH
8/2012-7/2014 Secretary, Department of Superintendent, KMUH
4/2010-3/2012 Secretary, Taiwan Surgical Society of Gastroenterology
8/2002-7/2004 Chief in Operation Room, Shiao-Kuang Municipal Hospital, Kaohsiung, Taiwan
Honor & Award
2009 Traveler’s Grant The 109th Annual Congress of Japan Surgical Society, April
2009 The First Place Award Thesis of The Year 2008, International College of Surgeons, Taiwan
2013 The First Place Award Thesis of The Year 2012, International College of Surgeons, Taiwan
Grant 近三年研究計畫
|
計畫名稱 |
補助機構 |
起訖日期 |
執行情形 |
計畫內擔任工作 |
經費總額 |
|
FGFR2/FOXM1增加Regorafenib之抗藥性與肝癌癌幹細胞生成(108-2314-B-037-100-MY2) |
科技部 |
2019/08/01~ |
執行中 |
主持人 |
2,300,000 |
|
高靈敏三族氮化物高電子移動率電晶體生物感測器之設計與應用(108-2320-B-110-004-) |
科技部 |
2019/08/01~ |
已結案 |
共同主持人 |
1,380,000 |
|
抑制HDAC-FOXM1可提高Sorafenib對肝癌癌幹細胞之毒殺效果(107-2314-B-037-026-) |
科技部 |
2018/08/01~ |
已結案 |
主持人 |
1,050,000 |
|
探討非酒精性脂肪胰疾病造成胰臟腺泡導管化生之病理及分子機轉(107-2635-B-037-002-) |
科技部 |
2018/08/01~ |
已結案 |
共同主持人 |
738,000 |
|
多環芳香烴化合物對肝癌之癌症幹細胞生成的影響(106-2320-B-037-001-MY3) |
科技部 |
2017/08/01~ |
已結案 |
共同主持人 |
4,157,000 |
|
以基模導向科技化評量用於訓練醫師臨床思辨能力之施行成效(106-2511-S-037-001-MY2) |
科技部 |
2017/08/01~ |
已結案 |
共同主持人 |
2,051,000 |
Selected paper
1. Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery. Wuputra K, Tsai MH, Kato K, Ku CC, Pan JB, Yang YH, Saito S, Wu CC, Lin YC, Cheng KH, Kuo KK, Noguchi M, Nakamura Y, Yoshioka T, Wu DC, Lin CS, Yokoyama KK. Inflamm Regen. 2023 Aug 18;43(1):42. doi: 10.1186/s41232-023-00290-6.IF=8.1; 28/161=23==17.31=9%( original)
2. Laparoscopic common bile duct exploration to treat choledocholithiasis in situs inversus patients: A technical review. Chiu BY, Chuang SH, Chuang SC, Kuo KK. World J Clin Cases. 2023 Mar 26;11(9):1939-1950. doi: 10.12998/wjcc.v11.i9.1939.IF=1.1; 135/167=80.84%( review)
3. Single-Incision Laparoscopic Pancreatoduodenectomy (Whipple Procedure) - a Pioneer Technical Report.
Chuang SH, Chuang SC, Kuo KK. J Gastrointest Surg. 2022 Nov;26(11):2402-2408. doi: 10.1007/s11605-022-05348-3. Epub 2022 Aug 1.IF=3.267; 66/211=31.28%( brief report)
4. FOXM1-CD44 Signaling Is Critical for the Acquisition of Regorafenib Resistance in Human Liver Cancer Cells.Wuputra K, Hsiao PJ, Chang WT, Wu PH, Chen LA, Huang JW, Su WL, Yang YH, Wu DC, Yokoyama KK, Kuo KK. Int J Mol Sci. 2022 Jul 14;23(14):7782. doi: 10.3390/ijms23147782.IF=6.208; 69/296=23.31%( original)
5. Correlation between Cancer Stem Cells, Inflammation and Malignant Transformation in a DEN-Induced Model of Hepatic Carcinogenesis. Wu CC, Lin CJ, Kuo KK, Chen WT, Ker CG, Chai CY, Tsai HP, Yang SF. Curr Issues Mol Biol. 2022 Jun 29;44(7):2879-2886. doi: 10.3390/cimb44070198. IF=2.976; 216/296=72.97%( original)
6. Stem Cell Biomarkers and Tumorigenesis in Gastric Cancer. Wuputra K, Ku CC, Pan JB, Liu CJ, Liu YC, Saito S, Kato K, Lin YC, Kuo KK, Chan TF, Chong IW, Lin CS, Wu DC, Yokoyama KK. J Pers Med. 2022 Jun 3;12(6):929. doi: 10.3390/jpm12060929. IF=3.508; 41/109=37.61%( review)
7. Single-incision versus four-incision laparoscopic transfistulous bile duct exploration for Mirizzi syndrome type II. Chuang SH, Kuo KK, Chuang SC, Wang SN, Chang WT, Su WL, Huang JW, Wu PH, Chan HM, Kuok CH. Surg Endosc. 2022 Nov;36(11):8672-8683. doi: 10.1007/s00464-022-09369-6. Epub 2022 Jun 13. IF=3.453; 60/211=28.44%( original)
8. Kung-Kai Kuo, Pi-Jung Hsiao, Wen-Tsan Chang, Shih-Chang Chuang, Ya-Han Yang, Kenly Wuputra, Chia-Chen Ku, Jia-Bin Pan, Chia-Pei Li, Kohsuke Kato, Chung-Jung Liu, Deng-Chyang Wu, and Kazunari K. Yokoyama. Therapeutic Strategies Targeting Tumor Suppressor Genes in Pancreatic Cancer. Cancers 2021, 13, 3920. https://doi.org/10.3390/cancers13153920.
9. Ju-Hui Wu, Chen-Yi Lee, Kung-Kai Kuo. The association between oral health status and the clinical outcome of cirrhotic patients on the waiting list for liver transplantation. Kaohsiung J Med Sci. 2021 Jul 19. doi: 10.1002/kjm2.12406.
10. Wuputra K, Tsai MH, Kato K, Yang YH, Pan JB, Ku CC, Noguchi M, Kishikawa S, Nakade K, Chen HL, Liu CJ, Nakamura Y, Kuo KK, Lin YC, Chan TF, Wu DC, Hou MF, Huang SK, Lin CS, Yokoyama KK. Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts. Cell Biol Toxicol. 2021 Mar 15. doi: 10.1007/s10565-021-09592-2.
11. Wang CY, Yin HL, Lee KT, Kuo KK. Extremely rare case of retroperitoneal "ancient" schwannoma with significant cystic change embedded in the psoas muscle. Kaohsiung J Med Sci. 2021 Jul;37(7):632-633. doi: 10.1002/kjm2.12366. Epub 2021 Feb 20.
12. Wen-Lung Su, Shih-Chang Chuang, Yu-Chu Wang, Lin-An Chen, Jian-Wei Huang, Wen-Tsan Chang, Shen-Nien Wang, King-Teh Lee, Chang-Shen Lin, Kung-Kai Kuo Expression of FOXM1 and Aurora-A predicts prognosis and sorafenib efficacy in patients with hepatocellular carcinoma. Cancer Biomark. 2020; 28(3): 341–350
13. Ker-Kong Chen, Kung-Kai Kuo, Ying-Chu Lin, Shigeo Saito, Chang-Shen Lin, Kazunari K. Yokoyama. Redox control in the pathophysiology of influenza virus infection. BMC Microbiol. 2020; 20: 214.
14. Hsin-Ying Clair Chiou, He-Jiun Jiang, Sheau-Fang Yang, Kung-Kai Kuo, Pi-Chen Lin, Pi-Jung Hsiao. Stemness regulation of the adrenal mixed corticomedullary tumorigenesis-a case-control study. Neoplasia. 2020 Jul; 22(7): 263–271.
15. CW Chang, PH Chen, SH Wang, SY Hsu, WT Hsu, CC Tsai, PV. Wadekar, S Puttaswamy, KH Cheng, S Hsieh, HY J. Wang, KK Kuo, Y Sun, Li-Wei Tu. Fast detection of tumor marker CA 19-9 using AlGaN/GaN high electron mobility transistors. Sensors and Actuators B: Chemical, 2018;267:191-197, (2/58=3.4%, Instruments & Instrumentation; IF 5.667, cited time: 7) ISSN 0925-4005, https://doi.org/10.1016/j.snb.2018.04.008.
16. Kuo KK, Lee KT, Chen KK, Yang YH, Lin YC, Tsai MH, Kenly Wuputra, Lee YL, Ku CC, Hiroyuki Miyoshi, Yukio Nakamura, Shigeo Saito, Wu CC, Chai CY, Richard Eckner, Lin CL Steve,Sophie S-W Wang, Wu DC, Lin CS, Kazunari K. Yokoyama. Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver. Stem cells.2016 Jun 24. doi: 10.1002/stem.2447. [Epub ahead of print]PMID:27341307 BIOTECHNOLOGY & APPLIED MICROBIOLOGYIF=5.902, 14/161=8.70%
17. Kuo KK, Kuo CJ, Chiu CY, Liang SS, Huang CH, Chi SW, Tsai KB, Chen CY, Edward Hsi, Cheng KH, Chiou SH* Quantitative Proteomic Analysis of Differentially Expressed Protein Profiles Involved In Pancreatic Ductal Adenocarcinoma. Pancreas. 2016 Jan 45(1): 71-83. SCI; GASTROENTEROLOGY & HEPATOLOGY, IF=2.959, 39/78=50%
18. Kuo KK, Wu BN, Liu CP, Yang TY, Kao LP, Wu JR, Lai WT, Chen IJ. Xanthine-based KMUP-1 improves -B1, LDL via LDLRs andHSL via PKA/PKG for hepatic fat loss. 2015 Nov J Lipid Res. 56(11):2070-84. SCI; BIOCHEMISTRY & MOLECULAR BIOLOGY, IF=4.421, 65/290=22.41%
19. Kuo, Kung-Kai, Jian, Shu-Fang; Li, Yi-Jin; Wan, Shi-Wei; Weng, Ching-Chieh; Fang, Kuan Te; Wu, Deng-Chyang; Cheng, Kuang-hung. Epigenetic Inactivation of TGFß1 Target Gene HEYL, a Novel Tumor Suppressor, Is Involved in the P53 Induced Apoptotic Pathway in Hepatocellular Carcinoma Hepatology Research 2014 (in press)
20. Hsiao PJ, Jao JC, Tsai JL, Chang WT, Jeng KS, Kuo KK. Inorganic arsenic trioxide induces gap junction loss in association with the downregulation of connexin43 and E-cadherin in rat hepatic "stem-like" cells. Kaohsiung J Med Sci. 2014 Feb;30(2):57-67.
21. Chiou SS, Wang SS, Wu DC, Lin YC, Kao LP, Kuo KK, Wu CC, Chai CY, Lin CL, Lee CY, Liao YM, Wuputra K, Yang YH, Wang SW, Ku CC, Nakamura Y, Saito S, Hasegawa H, Yamaguchi N, Miyoshi H, Lin CS, Eckner R, Yokoyama KK. Control of Oxidative Stress and Generation of Induced Pluripotent Stem Cell-like Cells by Jun Dimerization Protein 2. Cancers (Basel). 2013 Jul 26;5(3):959-84.
22. Hsieh HY, Lee WC, Senadi GC, Hu WP, Liang JJ, Tsai TR, Chou YW, Kuo KK, Chen CY, Wang JJ. Discovery, synthetic methodology, and biological evaluation for antiphotoaging activity of bicyclic[1,2,3]triazoles: in vitro and in vivo studies. J Med Chem. 2013 Jul 11;56(13):5422-35.
23. Hsiao PJ, Chen ZC, Hung WW, Yang YH, Lee MY, Huang JF, Kuo KK. Risk interaction of obesity, insulin resistance and hormone-sensitive lipase promoter polymorphisms (LIPE-60 C > G) in the development of fatty liver. BMC Med Genet. 2013 May 20;14:54.
24. Su HT, Weng CC, Hsiao PJ, Chen LH, Kuo TL, Chen YW, Kuo KK, Cheng KH.